Hani N Sabbah Selected Research

arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamide

1/2022	Elamipretide for Barth syndrome cardiomyopathy: gradual rebuilding of a failed power grid.
1/2021	Barth syndrome cardiomyopathy: targeting the mitochondria with elamipretide.
5/2020	Effects of Elamipretide on Left Ventricular Function in Patients With Heart Failure With Reduced Ejection Fraction: The PROGRESS-HF Phase 2 Trial.
4/2019	Effects of elamipretide on skeletal muscle in dogs with experimentally induced heart failure.
1/2018	Abnormalities of Mitochondrial Dynamics in the Failing Heart: Normalization Following Long-Term Therapy with Elamipretide.
12/2017	Novel Mitochondria-Targeting Peptide in Heart Failure Treatment: A Randomized, Placebo-Controlled Trial of Elamipretide.
2/2016	Chronic Therapy With Elamipretide (MTP-131), a Novel Mitochondria-Targeting Peptide, Improves Left Ventricular and Mitochondrial Function in Dogs With Advanced Heart Failure.
12/2014	Bendavia, a mitochondria-targeting peptide, improves postinfarction cardiac function, prevents adverse left ventricular remodeling, and restores mitochondria-related gene expression in rats.

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Hani N Sabbah Research Topics

Disease

107	Heart Failure 01/2022 - 03/2002
15	Hypertrophy 01/2017 - 05/2002
13	Left Ventricular Dysfunction 11/2012 - 05/2002
9	Fibrosis (Cirrhosis) 06/2017 - 09/2002
7	Ventricular Remodeling 01/2017 - 12/2006
6	Cardiomyopathies (Cardiomyopathy) 01/2022 - 09/2002
6	Hypertension (High Blood Pressure) 12/2013 - 10/2002
5	Mitochondrial Diseases (Mitochondrial Disease) 01/2017 - 01/2007
4	Inflammation (Inflammations) 01/2021 - 02/2009
4	Myocardial Infarction 08/2020 - 11/2012
4	Infarction (Infarctions) 02/2016 - 12/2005
4	Necrosis 07/2009 - 04/2004
4	Dilated Cardiomyopathy (Cardiomyopathy, Congestive) 08/2007 - 03/2002
3	Hyperemia 03/2017 - 02/2014
3	Hypoxia (Hypoxemia) 12/2008 - 09/2002
2	Barth Syndrome 01/2022 - 01/2021
2	Systolic Heart Failure 02/2021 - 11/2012
2	Cicatrix (Scar) 12/2020 - 12/2014
2	Ischemia 12/2020 - 12/2013
2	Cardio-Renal Syndrome 11/2020 - 03/2013
2	Disease Progression 11/2017 - 01/2017
2	Ventricular Dysfunction 01/2017 - 12/2005
2	Left Ventricular Hypertrophy (Ventricular Hypertrophy, Left) 12/2013 - 12/2006
2	Myocardial Ischemia (Ischemic Heart Diseases) 12/2009 - 12/2005
2	Mitral Valve Insufficiency (Mitral Regurgitation) 06/2005 - 12/2004
1	Rare Diseases (Rare Disease) 01/2021
1	Edema (Dropsy) 12/2020

Drug/Important Bio-Agent (IBA)

14	Proteins (Proteins, Gene)FDA Link 12/2013 - 03/2002
12	Messenger RNA (mRNA)IBA 12/2014 - 11/2003
9	Pharmaceutical PreparationsIBA 01/2022 - 03/2002
8	arginyl- 2,'6'- dimethyltyrosyl- lysyl- phenylalaninamideIBA 01/2022 - 12/2014
6	CalciumIBA 01/2017 - 11/2003
5	Adenosine Triphosphatases (ATPase)IBA 01/2021 - 03/2002
5	SodiumIBA 01/2013 - 05/2006
5	Fatty Acids (Saturated Fatty Acids)IBA 02/2012 - 12/2002
5	IstaroximeIBA 12/2009 - 01/2007
4	salicylhydroxamic acid (SHAM)IBA 12/2020 - 03/2003
4	EnzymesIBA 11/2020 - 12/2006
4	Peptides (Polypeptides)IBA 01/2018 - 12/2014
4	Reactive Oxygen Species (Oxygen Radicals)IBA 12/2016 - 01/2013
4	Natriuretic PeptidesIBA 12/2015 - 10/2013
4	CytokinesIBA 12/2014 - 02/2007
4	Glucose (Dextrose)FDA LinkGeneric 05/2013 - 10/2004
4	Ranolazine FDA Link 11/2008 - 08/2002
3	Biomarkers (Surrogate Marker)IBA 11/2020 - 07/2009
3	Therapeutic UsesIBA 12/2017 - 02/2009
3	Adenosine (Adenocard)FDA LinkGeneric 01/2017 - 05/2013
3	HydrogelsIBA 03/2016 - 06/2013
3	AlginatesIBA 03/2016 - 06/2013
3	AldosteroneIBA 12/2013 - 12/2002
3	Norepinephrine (Noradrenaline)FDA LinkGeneric 05/2013 - 03/2003
3	Metoprolol (Toprol-XL)FDA LinkGeneric 01/2009 - 09/2002
3	Matrix Metalloproteinases (MMPs)IBA 01/2008 - 06/2006
2	Neprilysin (Neutral Endopeptidase)IBA 11/2020 - 05/2002
2	Hydroxymethylglutaryl-CoA Reductase Inhibitors (HMG-CoA Reductase Inhibitors)IBA 08/2020 - 08/2007
2	nitroxylIBA 10/2018 - 11/2013
2	Biological ProductsIBA 01/2018 - 04/2004
2	Brain Natriuretic Peptide (Natrecor)FDA Link 12/2015 - 05/2013
2	Guanosine Monophosphate (5' Guanylic Acid)IBA 12/2015 - 03/2013
2	IvabradineIBA 12/2014 - 01/2014
2	Neurotransmitter Agents (Neurotransmitter)IBA 12/2014 - 02/2014
2	Docosahexaenoic AcidsIBA 12/2013 - 01/2013
2	LipidsIBA 12/2013 - 12/2006
2	DiureticsIBA 03/2013 - 05/2002
2	Oxidoreductases (Dehydrogenase)IBA 01/2013 - 08/2007
2	NADP (NADPH)IBA 01/2013 - 08/2007
2	Arginine Vasopressin (Argipressin)IBA 01/2013 - 01/2011
2	Unsaturated Fatty Acids (Polyunsaturated Fatty Acids)IBA 01/2013 - 02/2009
2	Nitric Oxide Synthase (NO Synthase)IBA 01/2012 - 01/2011
2	Carrier Proteins (Binding Protein)IBA 01/2012 - 06/2009
2	Vascular Endothelial Growth Factor A (Vascular Endothelial Growth Factor)IBA 01/2012 - 10/2005
2	Protein Isoforms (Isoforms)IBA 01/2012 - 11/2003
2	Phosphotransferases (Kinase)IBA 01/2012 - 01/2011
2	Phosphoric Monoester Hydrolases (Phosphatases)IBA 01/2012 - 03/2002
2	Rosuvastatin Calcium (Crestor)FDA Link 01/2012 - 08/2007
2	N-acetyltalosaminuronic acid (NAT)IBA 10/2011 - 05/2006
2	Adrenergic Receptors (Adrenergic Receptor)IBA 08/2011 - 01/2011
2	AdiponectinIBA 06/2010 - 02/2009
2	Milrinone (Primacor)FDA LinkGeneric 07/2009 - 01/2007
2	Caspase 3 (Caspase-3)IBA 12/2008 - 09/2002
2	Cytoskeletal ProteinsIBA 01/2008 - 12/2007
2	Eplerenone (Inspra)FDA LinkGeneric 12/2007 - 12/2002
2	Fibronectins (Fibronectin)IBA 12/2007 - 12/2005
2	VimentinIBA 12/2007 - 12/2005
2	Myosin Heavy Chains (Myosin Heavy Chain)IBA 12/2006 - 11/2003
2	Atrial Natriuretic Factor (ANF)IBA 12/2006 - 05/2002
2	Oxygen (Dioxygen)IBA 06/2005 - 12/2004
2	Adrenergic Agents (Adrenergic Drugs)IBA 04/2004 - 06/2002
2	Calcium-Calmodulin-Dependent Protein KinasesIBA 03/2003 - 03/2002
1	Sodium-Glucose Transporter 2 InhibitorsIBA 01/2022
1	ProteomeIBA 01/2021
1	CollagenIBA 12/2020
1	PlacebosIBA 12/2020

Therapy/Procedure

48	Therapeutics 01/2022 - 12/2002
6	Intravenous Infusions 02/2021 - 11/2008
5	Patient Readmission 01/2022 - 07/2008
4	Vagus Nerve Stimulation 12/2013 - 02/2009
3	Injections 03/2016 - 04/2011
3	Surgical Instruments (Clip) 01/2005 - 10/2002
2	Fat-Restricted Diet (Diet, Fat Restricted) 01/2012 - 12/2006